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The article proposes the joint study of an epigraphic and prosopographic appraisal on Domitius Zenophilus (cos. 333), a major figure of the Constantinian reign, and of the question of his symbolic figuration in the Actus Silvestri. By demonstrating the influence of Ephesian traditions on the choice of the judges of the Judeo-Christian controversy in these Actus Silvestri, it leads to formulate several hypotheses, among which the confirmation of his Asian proconsulate and of the attribution of the ILAfr 456 headless inscription, as well as a conversion to Christianity to be dated before his consulate, probably connected with this Asian period.