In 2012, the Ludwig Boltzmann Institute for archaeological prospection and virtual archaeology (LBI ArchPro) launched a strategic project with the focus on Mediterranean environments. It seemed to be necessary to test the applicability of various prospection techniques to achieve an integrative approach for documentation and investigation of archaeological sites in this environmental context. Therefore, adequate geographical areas have been selected to be systematically investigated within the project. This paper presents an overview of this research in the area of Osor. First, the case study area is presented, along with its specific archaeological questions. Next, the methodologies used to investigate these questions are detailed. Finally, the results are presented and discussed.